Novel inflammatory markers predict early tau pathology and synaptic damage in an elderly asymptomatic population at risk of Alzheimer’s disease
PREVENT-AD and ADNI; neuroinflammation, tau, synaptic integrity
Publications
Selected recent publications, 2019–2026.
A curated list emphasizing high-impact collaborative work and ADGEN/Poirier-led biomarker, genetics, inflammation, tau, synaptic, and PREVENT-AD studies.
Selected bibliography
Recent research contributions
This bibliography highlights recent ADGEN-led studies and major collaborative publications spanning biomarkers, genetics, neuroinflammation, imaging, synaptic biology, and Alzheimer’s disease prevention.
The IL-18 signaling cascade as a key mechanistic pathway in early Alzheimer’s disease pathogenesis
PREVENT-AD and ADNI; IL-18 pathway, early AD mechanisms
Humanized APOB mice translate molecular phenotypes across the Alzheimer’s disease spectrum
APOB, inflammatory biology, translational disease modeling
Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer’s disease
PREVENT-AD; imaging, tau, cognition
Longitudinal association between sleep and Alzheimer pathology
Sleep, longitudinal pathology, prevention cohort
Prevalence and characterization of tau PET positivity in individuals with and without cognitive impairment
International tau PET collaboration with PREVENT-AD contribution
Plasma p-tau217 identifies cognitively normal older adults who develop cognitive impairment in a 10-year window
Blood biomarker trajectories and prediction
Quantitative MRI of the hippocampus reveals microstructural trajectories of aging and Alzheimer’s disease pathology
MRI, hippocampal microstructure, aging and pathology
Reducing CETP activity prevents memory decline in an Alzheimer’s disease mouse model
CETP activity, memory, therapeutic biology
SERPINE1 correlates with brain and CSF biomarkers associated with sporadic Alzheimer’s disease
CSF/brain biomarker integration
Precuneus activity during retrieval is positively associated with amyloid burden in cognitively normal older APOE4 carriers
APOE4, amyloid, memory retrieval networks
Protocol for an intergenerational randomized controlled trial to enhance physical activity in older adults at risk for Alzheimer’s disease
Lifestyle intervention and prevention
Cerebrospinal fluid and brain PET measures of synaptic vesicle glycoprotein 2A: biomarkers of synaptic density in Alzheimer’s disease
SV2A PET, CSF biomarkers, synaptic density
Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status
PREVENT-AD; neuromodulatory systems, APOE, tau
Apolipoprotein B gene expression and regulation in relation to Alzheimer’s disease pathophysiology
APOB, gene expression, Alzheimer pathophysiology
PTPRS is a novel marker for early tau pathology and synaptic integrity in Alzheimer’s disease
Tau, synaptic integrity, PREVENT-AD biomarker biology
Osteopontin is associated with Alzheimer’s disease pathology in at-risk individuals and is elevated in the frontal cortex of a large sample of autopsy-confirmed Alzheimer brains
PREVENT-AD, ADNI, autopsy-confirmed AD
Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E ε4 allele carriers
APOE4 and sleep physiology
Insulin-like growth factor-binding protein 2 in asymptomatic individuals and autopsy-confirmed AD
PREVENT-AD, ADNI, neuropathology integration
Longitudinal blood biomarker trajectories in preclinical Alzheimer’s disease
Blood biomarkers and preclinical disease trajectories
Characterization of the contactin 5 protein and its risk-associated polymorphic variant throughout the Alzheimer’s disease spectrum
CNTN5, genetics, disease spectrum
A prognostic risk score for development and spread of chronic pain
High-impact collaborative systems-risk modelling
How do modifiable risk factors affect Alzheimer’s disease pathology or mitigate its effect on clinical symptom expression?
Modifiable risk factors, pathology, clinical expression
APOE ε2 versus APOE ε4 dosage shows sex-specific links to hippocampus-default network subregion co-variation
APOE dosage, sex-specific brain network effects
Publication status
Manuscripts under review or revision are clearly identified and will be updated when formal publication details become available. Published entries link to journal or DOI records where available.